Research shows that melatonin can be effective at reducing anxiety before surgical or medical procedures.īut it isn’t clear if it can help with other forms of anxiety, such as generalized anxiety disorder, social anxiety, and panic attacks. In this study, melatonin worked better than a placebo sugar pill to improve sleep and decrease symptoms of depression and anxiety. One older study also evaluated the effects of melatonin in older adults with sleep and mood disorders. In this study, melatonin worked better than oxazepam for improving sleep and reducing symptoms of anxiety. In another 2018 study, melatonin was evaluated in people who had just undergone a medical procedure to open up blood vessels in the heart. One 2018 study found that melatonin worked about as well as alprazolam for reducing anxiety before surgery. Some studies also found that melatonin reduced symptoms of anxiety after surgery, but other studies found no benefit. Most of the studies analyzed found that taking melatonin worked better than a placebo pill and about as well as midazolam for reducing anxiety before the procedure. In a 2015 analysis of clinical studies, melatonin was compared to either midazolam or a placebo sugar pill when given before surgery. It’s common for people to feel anxious before surgery and medications such as benzodiazepines are typically used to reduce these symptoms. Most of the human research on melatonin has been done in people who are undergoing a surgical procedure. Other medications commonly used for anxiety, such as benzodiazepines, also increase GABA levels. Higher GABA levels can have a calming effect and reduce symptoms of anxiety. In one 2017 animal study, melatonin increased levels of gamma-aminobutyric acid (GABA) in certain parts of the brain. In addition to improving sleep, melatonin has other effects that might improve symptoms of anxiety.
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